Brand name : Depo-Provera
Pronounced: DE-po pro-VEH-ra
Generic name: Medroxyprogesterone acetate
Why is Depo-Provera prescribed?
Depo-Provera Contraceptive Injection is given in the buttock or upper
arm to prevent pregnancy. It is more than 99 percent effective; your
chances of becoming pregnant during the first year of use are less
than 1 in 100. The injection is given every 3 months (13 weeks) by
your doctor. Depo-Provera works by preventing the release of hormones
called gonadotropins from the pituitary gland in the brain. Without
these hormones, the monthly release of an egg from the ovary cannot
occur. If no egg is released, pregnancy is impossible. Depo-Provera
also causes changes in the lining of the uterus that make pregnancy
less likely even if an egg is released.
In higher doses, Depo-Provera is also used in the treatment of certain
cancers including cancer of the endometrium (lining of the uterus)
and kidney cancer.
Most important fact about Depo-Provera without a prescriptions
Because Depo-Provera is a long-acting form of birth control, it will
take a while for the effects of your last injection to wear off. In
medical studies, only 68 percent of women became pregnant within 12
months after stopping Depo-Provera. However, within 18 months, 93 percent
had become pregnant. If you think you will want to get pregnant shortly
after you stop using birth control, Depo-Provera may not be the ideal
method for you. The amount of time you use Depo-Provera does not affect
the delay in becoming pregnant when you stop.
How should you take Depo-Provera?
Depo-Provera is given by a doctor. To make sure you are not pregnant
when you receive your first injection, it is given only during the
first 5 days after your menstrual period, when it is very unlikely
that you could be pregnant. If you are breastfeeding, Depo-Provera
is given 6 weeks after childbirth to reduce the infant's exposure to
the drug through breast milk. If you are not breastfeeding, it is given
within 5 days of childbirth.
Depo-Provera must be taken every 3 months (13 weeks), on schedule.
Although the birth-control effects of the drug generally take time
to wear off, there is still a possibility of becoming pregnant right
away if you miss your scheduled injection.
Why should Depo-Provera not be prescribed?
You should not use Depo-Provera if you know or suspect you are pregnant,
or if you have unusual vaginal bleeding that has not been diagnosed
by a doctor.
Also avoid Depo-Provera if you know or suspect you have breast cancer,
or if you have liver disease.
Do not use this method of birth control if you have thrombophlebitis
(inflammation of a vein with development of a blood clot), or have
ever had any blood-clotting disorders, such as a stroke, or disease
of the blood vessels in the brain.
You should not take Depo-Provera if you have ever had an allergic
reaction to it or to any of its ingredients.
--If you miss a dose...
If you allow more than 13 weeks to elapse before your next injection,
your doctor will do a test to make sure you are not pregnant before
giving you another injection.
--Storage instructions...
Depo-Provera is always given at a doctor's office or clinic, never
at home.
Depo-Provera side effects
Side effects cannot be anticipated. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can determine
if it is safe for you to continue taking Depo-Provera.
By far, the most common side effect of Depo-Provera is unpredictable
menstrual bleeding. In fact, most women have some change in their menstrual
pattern. For example, when first taking Depo-Provera, it is common
to have spotting between menstrual periods, or an increase or decrease
in the amount of bleeding when menstrual periods occur. With continued
use, many women stop having their menstrual periods altogether.
By 12 months (or four injections), 55 percent of women report not
having periods, and by 24 months, 68 percent no longer have periods.
Going without a menstrual period is not an indication that something
is wrong, however.
* Side effects may include:
Abdominal pain or discomfort, dizziness, headache, nervousness, unpredictable
menstrual bleeding, weakness or fatigue, weight gain or loss
Special warnings about Depo-Provera
Call your doctor immediately if any of these problems occur after
an injection of Depo-Provera: sharp chest pain, coughing of blood,
sudden shortness of breath, sudden severe headache or vomiting, dizziness
or fainting, problems with your eyesight or speech, weakness or numbness
in an arm or leg, severe pain or swelling in the calf, unusually heavy
vaginal bleeding, severe pain or tenderness in the lower abdominal
area, migraine headache, or persistent pain, pus, or bleeding at the
injection site.
Studies indicate that using Depo-Provera may make you more prone to
osteoporosis, or brittle bone disease. The rate at which bone loss
occurs is greatest during the early years of Depo-Provera use, and
the risk decreases to normal over time.
Studies of women who have used Depo-Provera for a long time have found
virtually no increased risk of cancers of the breast, ovaries, liver,
or cervix (mouth of the uterus). Some studies do show a slight increased
risk of breast cancer in women younger than 35 years old who have taken
Depo-Provera for a short time, but the increase is about three additional
cases of breast cancer per 10,000 women. At the same time, Depo-Provera
helps reduce the chance of cancer of the endometrium, or lining of
the uterus.
Depo-Provera may cause fluid retention, so if you have conditions
that may be worsened by fluid retention, such as epilepsy, migraine
headaches, asthma, heart disease, or kidney disease, make sure the
doctor is aware of it.
Depo-Provera tends to alter levels of blood sugar, so diabetic women
need to be carefully observed by their doctors when taking Depo-Provera.
If you develop jaundice (a yellowing of the skin and whites of the
eyes caused by liver disease), you probably should not receive Depo-Provera
again.
Most women gain weight while they are using Depo-Provera.
While it is an excellent birth control method, Depo-Provera does not
protect you against AIDS or other sexually transmitted diseases. If
you are concerned about AIDS or other STDs, be sure your partner uses
a condom during intercourse (or, for absolute safety, abstain from
sex).
Before you start using Depo-Provera, be sure to tell your doctor if
you or anyone in your family has ever had breast cancer; if you have
ever had any problems with your breasts; if your menstrual periods
have ever been irregular or spotty; if you have kidney disease, high
blood pressure, migraine headaches, asthma, epilepsy, or a history
of depression; if you or anyone in your family has or has had diabetes;
or if you are taking any prescription or over-the-counter drugs.
Possible food and drug interactions when taking Depo-Provera
If Depo-Provera is taken with aminoglutethimide (Cytadren), a drug
used to treat a disorder of the adrenal glands called Cushing's syndrome,
it could make the Depo-Provera less potent, which could lead to unexpected
pregnancy. Check with your doctor before taking Cytadren if you are
on Depo-Provera.
Special information if you are pregnant or breastfeeding
Depo-Provera is not given to pregnant women. If an unexpected pregnancy
occurs 1 to 2 months after a Depo-Provera injection, the baby is more
likely to have a low birth weight or other health problems; birth defects
are possible if you use the drug during the first 3 months of pregnancy.
Children born to women who were taking Depo-Provera show no signs of
poor health or development. Because Depo-Provera does not prevent the
breasts from producing milk, it can be used by women who are breastfeeding.
However, to minimize the amount of Depo-Provera that is passed to the
infant during the first weeks of life, the drug is not given until
6 weeks after childbirth. Studies show Depo-Provera is not harmful
to the infant then or later in life.
Recommended dosage for Depo-Provera
Depo-Provera is given as a single 150-milligram injection every 3
months (13 weeks).
Overdosage
