Product Description ROXID (Roxithromycin)
Roxithromycin is an oral macrolide antibiotic with broad spectrum coverage
against both gram +ve, gram -ve and atypical pathogen causing RTI.
Serratiopeptidase is a proteolytic enzyme derived from serrati SPP.
Serratiopeptidase is a proven proteolytic enzyme that exerts a direct
mucolytic action breaks the mucus and promotes expectoration and helps
in antibiotic penetration.
Mechanism of Action
Roxithromycin acts by binding to 50's ribosomal sub unit of bacteria
and inhibit the protein synthesis.
Serratiopeptidase binds to alpha-2 macroglobulin in the blood in the
ratio of 1:1 which helps to mask its antigenicity but retain its enzymatic
activity by hydrolysing bradykinin, histamine, and serotonin. Serratiopeptidase
blocks plasmin inhibition thus helping the fibrinolytic activity of
plasmin helps clearance of exudate, reduces swelling and improves micro
circulation.
Pharmaco Kinetics
Roxithromycin is well absorbed with peak serum concentration of about
8-10mcg/ml within 1-2 hrs,duration of action ranges from 8-12hrs.The
Bio-availability of Roxithromycin improves if it is taken in empty
stomach.
Indications
In URTI like sinusitis, pharyngitis, tonsillitis, Uro genital infection,
skin and soft tissue infection.
Dosage ROXID (Roxithromycin)
Roxithromycin recommended dosage for adults is 150mg BID. Serratiopeptidase
recommended dosage is 15 to 30mg daily in divided dose. Hence the
dosage for Roxidase is One Tablet BID before food.
Contra Indication
Hypersensitivity to macrolides and serratiopeptidase.
Drug Interactions
With Digoxin, Midazolam, Terfenadine, Disopyramide
Product Rationale
Most often URTI the problem is infection, inflammation, and retained
secretion. In SSTI and urogenital infection, problem is infection,
inflammation, penetration of antibiotic. Roxithromycin can take care
of infection only. Serratiopeptidase is an anti inflammatory, proteolytic
and anti fibrinolytic enzyme helps in reducing inflammation, retained
secretion and penetration of antibiotic. So by combining these two
drugs it will provide synergistic effect and will help in faster
and complete cure than plain Roxithromycin.
Special Precautions
Liver cirrhosis, pregnancy, severe hepatic and renal impairments.
Packing
A Blister Strip of 10 tablets
In a box 2x5x10 tablets
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