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Phentermine the most important consumer information:

Brand name:
Phentermine

Generic Name: phentermine (FEN ter meen)
Brand names:

Adipex P (Immediate release)
Anoxine-AM
Ionamin (Slow Release Resin, Australia, discontinued in the US) Duromine (Slow Release Resin, New Zealand, Australia & South Africa) Fastin
Mirapront Obephen Obermine Obestin-30 Phentremene Phentrol Phenterex Phentromin
Pro-Fast SA Redusa Panbesy Phentermine Trenker Obenix
Oby-Trim Teramine
Zantryl Sinpet (MX) Supremin (PH)
Umine (NZ) Weltmine (KP)
Phentermine Description : What is phentermine.

Phentermine, a contraction for "phenyl-tertiary-butylamine", is an appetite suppressant of the amphetamine and phenethylamine class.

It is approved as an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification. It is typically prescribed for individuals who are at increased medical risk because of their weight and works by helping to release certain chemicals in the brain that control appetite.

History

--

Phentermine is a stimulant that is similar to an amphetamine. It is an appetite suppressant that affects the central nervous system.

Phentermine is used togther with diet, exercise and behavioral modification to treat obesity (excessively overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes.Phentermine may also be used for other purposes not listed in this medication guide.Phentermine hydrochloride, USP has the chemical name of a,a-Dimethylphenethylamine hydrochloride. The structural formula is as follows:

Phentermine hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether.Phentermine hydrochloride, an anorectic agent for oral administration, is available as a capsule containing 15 mg, 30 mg or 37.5 mg of Phentermine hydrochloride (equivalent to 12 mg, 24 mg and 30 mg respectively of Phentermine base) and as a tablet containing 37.5 mg of Phentermine hydrochloride (equivalent to 30 mg of Phentermine base).Phentermine hydrochloride capsules 15 mg contain the inactive ingredients D&C Yellow #10 Aluminum Lake, FD&C Blue #1 Aluminum Lake, FD&C Red #3, FD&C Red #40 Aluminum Lake, Gelatin, Lactose Monohydrate, Magnesium Stearate, Talc and Titanium Dioxide.

Phentermine hydrochloride capsules 30 mg and 37.5 mg contain the inactive ingredients D&C Red #33 (in 37.5 mg only), D&C Yellow #10 Aluminum Lake, FD&C Blue #1 Aluminum Lake, FD&C Blue #2 Aluminum Lake, FD&C Red #3 (in 30 mg only), FD&C Red #40 Aluminum Lake, Gelatin, Lactose Monohydrate, Magnesium Stearate, Pharmaceutical Glaze, Propylene Glycol, Silicon Dioxide, Sodium Lauryl Sulfate, Synthetic Black Iron Oxide, Talc and Titanium Dioxide.

Phentermine hydrochloride capsules 30 mg (Seed Formulation) contain the inactive ingredients D&C Red #28, FD&C Blue #1, FD&C Blue #2 Aluminum Lake, FD&C Red #40 Aluminum Lake, D&C Yellow #10 Aluminum Lake, Gelatin, n-Butyl alcohol, Pharmaceutical Glaze, Propylene Glycol, Povidone, Starch, Sucrose, Synthetic Black Iron Oxide and Talc.

Phentermine hydrochloride tablets 37.5 mg contain the inactive ingredients Anhydrous Lactose, Colloidal Silicon Dioxide, Corn Starch, FD&C Yellow #6 Aluminum Lake, FD&C Blue #1, Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Stearic Acid and Sucrose.

Warnings

Phentermine hydrochloride tablets and capsules are indicated only as short-term monotherapy for the management of exogenous obesity. The safety and efficacy of combination therapy with Phentermine and any other drug products for weight loss, including selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. Therefore, coadministration of these drug products for weight loss is not recommended.

Primary Pulmonary Hypertension (PPH) – a rare, frequently fatal disease of the lungs – has been reported to occur in patients receiving a combination of Phentermine with fenfluramine or dexfenfluramine. The possibility of an association between PPH and the use of Phentermine alone cannot be ruled out; there have been rare cases of PPH in patients who reportedly have taken Phentermine alone. The initial symptom of PPH is usually dyspnea. Other initial symptoms include: angina pectoris, syncope or lower extremity edema. Patients should be advised to report immediately any deterioration in exercise tolerance. Treatment should be discontinued in patients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or lower extremity edema.

Valvular Heart Disease: Serious regurgitant cardiac valvular disease, primarily affecting the mitral, aortic and/or tricuspid valves, has been reported in otherwise healthy persons who had taken a combination of Phentermine with fenfluramine or dexfenfluramine for weight loss. The etiology of these valvulopathies has not been established and their course in individuals after the drugs are stopped is not known. The possibility of an association between valvular heart disease and the use of Phentermine alone cannot be ruled out; there have been rare cases of valvular heart disease in patients who reportedly have taken Phentermine alone.

Tolerance to the anorectic effect usually develops within a few weeks. When this occurs, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued.Phentermine hydrochloride may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; the patient should therefore be cautioned accordingly.Usage with Alcohol: Concomitant use of alcohol with Phentermine hydrochloride may result in an adverse drug interaction.

Pregnancy :Teratogenic Effects

Pregnancy Category C. Animal reproduction studies have not been conducted with Phentermine hydrochloride. It is also not known whether Phentermine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Phentermine hydrochloride should be given to a pregnant woman only if clearly needed.

Nursing Mothers :

Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use phentermine without Rx/Prescriptions

Safety and effectiveness in pediatric patients have not been established.

Overdosage

Manifestations of acute overdosage with Phentermine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma.

Management of acute Phentermine intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard. Acidification of the urine increases Phentermine excretion. Intravenous phentolamine has been suggested for possible acute, severe hypertension, if this complicates Phentermine overdosage.

Before taking phentermine
Do not take phentermine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take phentermine before the MAO inhibitor has cleared from your body.

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor's advice.
Do not take this medication if you are allergic to phentermine or other stimulants, or if you have:

heart disease or high blood pressure;
arteriosclerosis (hardening of the arteries); an overactive thyroid;
glaucoma;if you are in an agitated state; or
if you have a history of drug or alcohol abuse.Before taking phentermine, tell your doctor if you are allergic to any drugs, or if you have: a thyroid disorder; anxiety disorder; diabetes; or epilepsy or another seizure disorder.

Phentermine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using phentermine and call your doctor at once if you have any of these serious side effects:feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
chest pain, fast or uneven heartbeat, feeling like you might pass out;
unusual thoughts or behavior, feeling restless or confused; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

enerally, phentermine appears to be relatively well tolerated.[5] It can produce side effects consistent with its catecholamine-releasing properties, e.g., tachycardia (increased heart rate) and elevated blood pressure, but the incidence and magnitude of these appear to be less than with the amphetamines. Because phentermine acts through sympathomimetic pathways, the drug may increase blood pressure and heart rate. It may also cause palpitations, restlessness, and insomnia. Additionally, phentermine has the potential to cause physical and psychological dependence.

More common :

Insomnia Hypertension Irritability Nervousness Euphoria Dry mouth Unpleasant taste Blurred vision Heartburn/Acid reflux Changes in libido Clumsiness
Confusion Diarrhea Dizziness Headache Arrhythmia Nausea or vomiting Psychosis Skin rash or itching Stomach pain Fatigue

Less common

onvulsions (seizures) Dizziness Fever Hallucinations Hostility with urge to attack Irregular blood pressure Lightheadedness or fainting Periods of mania ollowed by period of depression Tremors, trembling or shaking Overactive reflexes Panic Restlessness Severe nausea, vomiting or diarrhea Stomach ramps Weakness

Less serious side effects may include:

feeling nervous or anxious;
headache, dizziness, tremors;
trouble sleeping (insomnia);
dry mouth or an unpleasant taste in your mouth;
diarrhea or constipation; or
itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

If you have any of these conditions, you may need a dose adjustment or special tests during treatment.
It is not known whether phentermine will harm an unborn baby. Do not take phentermine without telling your doctor if you are pregnant. It is also not known whether phentermine passes into breast milk or if it could harm a nursing baby. Do not take phentermine without telling your doctor if you are breast-feeding a baby. Do not give this medication to anyone younger than 16 years old without the advice of a doctor. Phentermine may be habit-forming and should be used only by the person it was prescribed for. Phentermine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

 

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Nimsim Niquick Nitdin Nitrazopam Nitrofurantoin Nitrofurantoine Nitroquik Nitrosorbon Nivant Nizoral Nolotil Nolvadex Nootropil Noragyl Norco Nordette Noreta Norethindrone Norflox Norfloxacin Noroxin Nortriptyline Norvasc Novamox Novir Novolog Nubain Nuegaba Nuprin Nurofen Nysta Nystatin Obelin Obesitas Obestat Obsidan Ocella Ocubrax Ocuflox Oestraclin Oestradiol Ofloxacin Okamet Olanazapine Olanzapine Oliza Olmetec Olmy Omeprazol Omeprazole Omnacortil Omnipred Omoxcillin Ondansetron Oretic Orlistat Ornidazole Orphenadrine Otrivin Ova Ovestin Ovral Ovranette Oxcarbazepine Oxibutynin Oxy Oxybutin Oxymetazoline Oxytetracycline Oxytocin Pamelor Pamidronate Pamoxan Panadol Panasol Panmycin Pansol Pantocid Paracetamol Paracip Paraxin Pariet Parlodel Parnate Paroketine Paroxetine Paxil Pazbronquial Penetrex Penicillin Penlac Pentalong Pentobarbital Pentoxifyllin Pentoxifylline Pepcid Peptaz Peptazole Percecet Percocet Percoset Perenterol Pergolide Periactin Perindopril Periostat Permikson Persantine Persoet Perstatin Petheal Pharmagrip Phendimetrazine Phenergan Pheniramine Phentermine Phentrol Phenylbutazone Phenytoin Phetoin Phezam Phyllocontin Pigmentasa Piozone Piptazole Piribedil Piroxgel Piroxicam Pitocin Plaquenil Plavix Plendil Ponstan Ponstel Prandin Prava Pravachol Pravastatin Pravix Prazol Precose Prednisolone Prednisone Pregabalin Pregablin Pregeb Pregnyl Pregynl Premabolin Premarin Premia Premphase Prenarun Prepro Prepulsid Prevacid Prevpac Prilosec Primaquine Primetanid Priminer Primolut Progesterone Proglumide Progynova Propanolol Propecia Propranadol Propranolol Propulsid Prosac Proscar Proscarr Prostagalen Protronix Provera Provers Provigil Proviron Proxyvon Prozac Prozax Pulmicort Punstan Puregon Purinethol Pyritinol Quinapril Quineprox Quinine Qvar Rabeprazole Rabifin Racecadotril Radispasmin Raloxifene Ramilich Ranitidine Reclide Reclon Reductil Regaine Regestrone Registrone Reglan Relana Relax Remeron Renagel Renedil Renova Repaglinide Resperidol Respibien Respitol Respulmin Resteclin Restoril Retarpen Retin Retino Retinova Retrovir Rezult Rhim Rhinocort Ribavirin Riclide Rilatine Rimonaband Rimonabant Risdone Risperdal Risperidona Risperidone Ritalin Rivastigmine Rivatrol Rivotil Rivotril Roaccutane Robaxin Robinul Rocephin Rococet Rofecoxib Rogaine Rohypnol Roliten Romesec Romilast Ropark Ropinirole Rosiglitazone Rosuvas Rosuvastatin Rosuvastin Rotahaler Rovamy Rowanefrin Rowasa Roxithromycin Rulide Rupafin Rupatandine Rx Rythmol Sabrilex Salagen Salbutamol Saldiart Salil Salmeterol Salmeterol_fluticasone Salmoncal Salvacolina Sanbeflam Sandoz Saridon Schaper Scop Scopoderm Scopolamine Sdrax Seconal Selegiline Selgin Seloppres Selopres Sempera Sensor Sepcen Septra Septran Serc Seretide Serevent Serlift Serline Serobid Seroflo Seroquel Sertraline Servier Serzone Setraline Shelcal Shipping Sibutramine Sibutrim Sign Sildeafil Sildenafil Silver Simcard Simvastatin Sinamet Sinemet Sinequan Singulair Singular Sinvastatin Siphene Sizodon Skelact Skin Sleep Sleeping Slenderpet Slimex Sobelin Sobril Sodium Solcoseryl Soma Somit Sorbitrate Soriatane Sotahexal Sotalex Sotaloft Spasmex Spasmoctyl Spasmonil Spiramycin Spiriva Spironolactone Sporanox Sporidex Spraxin Spriva Stadol Stamlo Stanozolol Stavudine Stemetil Stemitil Stepro Steroids Stilnox Stimate Strattera Suboxone Sumatriptan Sumycin Supracal Supradine Supradyn Suprax Sustiva Symmetrel Synalar Synermox Synthroid Syntosinon Tadalafil Tafil, Tagamet Talcid Tamazepam Tamiflu Tamoxide Tamoxifen Tapazol Tapazole Tardyferon Tarmed Taxim Taxotere Taxotiri Tegaserod Tegopen Tegretol Telfast Telmisartan Temazepam Temovate Ten Tenoretic Tenoretis Tenoric Tenormin Tenoxicam Terazoflo Terazosin Terbiderm Terbinafine Terbutaline Terfenadin Termalgin Terol Testerone Testim Testo Testoderm Testogel Testosteron Testosterone Tetracyclin Tetracycline Tetracyline Tetradox Tetrazepam Tetrex Theochron Theochront Theofylin Theophylline Thiamazol Thyroxine Tianeptine Tiaprd Tibofem Tibolone Ticlopidine Timolol Tindamax Tiova Tizanidine Topamac Topamax Topimax Toprol Tranexamic Tranquinal Tranqulizer Transgender Tranxene Trapax Travoprost Trazadone Tretinoin Trifeme Trileptal Trilombrin Trimetabol Trinessa Triotrinina Tritace Trivastal Tryptanol Tylox Ubretid Udiliv Ultram Uniwarfin Urbanol Urispas Urotone Valcoter Valcye Valcyte Valerin Valium Valparin Valsartan Valtrex Vancenase Vandril Vaniqa Vanoxide Vantin Vardenafil Varenicline Vasotec Vasotrate Vectavir Ventolin Verapamil Vertin Viagra Vibramycin Vicadin Vicomin Vigicer Viramune Viternun Voltaren Voveran Warf Warfarin Wellbutrin Wellprutin Xalatan Xanax Xenical Xet Xylocaine Xyzal Yasmin Yerba Yohimbin Yohimbine Zanaflex Zanax Zanidip Zantac Zebeta Zertalin Zestoretic Zestril Zetia Zevit Ziac Zidovir Zidovudine Zimovane Ziprasidone Zirtec Zithromax Zithromycin Zitromax Zocor Zofonex Zofran Zolfresh Zolipdem Zolmitriptan Zoloft Zolomide Zolpidem Zolpiderm Zopiclone Zoplicone Zoton Zovirax Zyban Zyprexa Zyrtec
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