Brand name:
STAVIR (Stavudine, Zerit, d4T)
Pronounced: ZAIR-it
Generic name: Stavudine
Why is STAVIR (Stavudine, Zerit, d4T) prescribed?
STAVIR (Stavudine, Zerit, d4T) is one of the drugs used to fight the human immunodeficiency
virus (HIV)--the deadly cause of AIDS. It is usually prescribed for
people who have already been taking the HIV drug Retrovir for an extended
period. HIV attacks the immune system, slowly destroying the body's
ability to fight off infection. STAVIR (Stavudine, Zerit, d4T) helps stave off the attack by
disrupting the virus's ability to reproduce.
Signs and symptoms of HIV infection include diarrhea, fever, headache,
infections, problems with the nervous system, rash, sore throat, and
significant weight loss.
Most important fact about STAVIR (Stavudine, Zerit, d4T)
Although STAVIR (Stavudine, Zerit, d4T) can slow the progress of HIV infection, it is not a
cure. Because of the continuing danger of complications and infections,
you should get frequent physical exams and blood counts. Be sure, too,
to notify your doctor immediately if you experience any changes in
your general health.
How should you take STAVIR (Stavudine, Zerit, d4T)?
Take STAVIR (Stavudine, Zerit, d4T) every 12 hours, exactly as prescribed. It's important to
keep a constant level of the drug in the body, so be sure to take each
dose on schedule. Do not take more than the prescribed amount; nerve
disorders could result.
Shake the oral solution vigorously before measuring the dose.
You can take STAVIR (Stavudine, Zerit, d4T) with or without food.
If you miss a dose...
Take it as soon as you remember. If it is almost time for your next
dose, skip the one you missed and go back to your regular schedule.
Do not take 2 doses at once.
Storage instructions...
Keep the STAVIR (Stavudine, Zerit, d4T) container tightly closed. Store the capsules at room
temperature. Store STAVIR (Stavudine, Zerit, d4T) oral solution in the refrigerator; throw out
any unused medication after 30 days.
STAVIR (Stavudine, Zerit, d4T) side effects
Side effects are more likely if you combine STAVIR (Stavudine, Zerit, d4T) with other drugs
that cause similar reactions. Also, the higher your dosage of STAVIR (Stavudine, Zerit, d4T),
the greater the chance of a problem. However, it's often hard to tell
a side effect from a symptom of the disease. If you think the drug
is causing problems, keep taking it until you've checked with your
doctor. Only your doctor can determine whether the drug is at fault,
and adjust your dosage accordingly.
* Side effects may include:
Abdominal pain, allergic reaction, chills, diarrhea, fever, headache, liver
damage, loss of appetite, muscle pain, nausea and vomiting, nervous system
abnormalities, pain or numbness and tingling in the hands and feet, pancreatitis,
rash, sleeplessness
Why should STAVIR (Stavudine, Zerit, d4T) not be prescribed?
If STAVIR (Stavudine, Zerit, d4T) gives you an allergic reaction, you should not take the drug.
Special warnings about STAVIR (Stavudine, Zerit, d4T)
Remember that STAVIR (Stavudine, Zerit, d4T) does not prevent the spread of HIV through sexual
contact or contact with infected blood.
STAVIR (Stavudine, Zerit, d4T) has been known to cause severe and even fatal liver damage,
especially in women, overweight individuals, and people who have been
taking STAVIR (Stavudine, Zerit, d4T) or similar medications for a long time. The risk increases
if you're being treated with a combination of STAVIR (Stavudine, Zerit, d4T), Videx, and hydroxyurea.
Signs of a liver problem include weakness, fatigue, abdominal pain,
nausea, vomiting, and shortness of breath. If you develop these symptoms,
call your doctor immediately; treatment with STAVIR (Stavudine, Zerit, d4T) may have to be stopped.
Also be sure to tell the doctor if you've ever had a liver problem
or tend to abuse alcohol; the doctor will watch especially closely
for any sign of a liver problem.
STAVIR (Stavudine, Zerit, d4T) can also cause serious and even fatal pancreatitis, especially
if you've had the problem in the past, suffer from gallstones, or drink
alcoholic beverages. Combining STAVIR (Stavudine, Zerit, d4T) with Videx increases the risk.
Check with your doctor immediately if you develop such signs of pancreatitis
as stomach pain, nausea, or vomiting; you may have to stop treatment
with STAVIR (Stavudine, Zerit, d4T). If you have any of the risk factors for pancreatitis, make
sure the doctor is aware of it.
One of the more common and dangerous side effects of STAVIR (Stavudine, Zerit, d4T) is a problem
called peripheral neuropathy, a serious condition in which certain
nerves are damaged. If you notice numbness, tingling, or pain in your
hands or feet, notify your physician immediately. Treatment with STAVIR (Stavudine, Zerit, d4T)
may have to be stopped.
Another side effect seen in some people receiving drugs for HIV is
a redistribution of body fat, leading to extra fat around the middle,
a "buffalo hump" on the back, and wasting in the arms, legs,
and face. Researchers don't know whether this represents a long-term
health problem or not.
The benefit you get from STAVIR (Stavudine, Zerit, d4T) may not last long. If your symptoms
begin to get worse, tell your doctor immediately.
Possible food and drug interactions when taking STAVIR (Stavudine, Zerit, d4T)
Combining STAVIR (Stavudine, Zerit, d4T) with any of the following drugs may make peripheral
neuropathy worse.
Chloramphenicol (Chloromycetin)
Cisplatin (Platinol)
Dapsone
Didanosine (Videx)
Ethambutol (Myambutol)
Hydralazine (Apresoline)
Lithium (Eskalith, Lithobid)
Metronidazole (Flagyl)
Nitrofurantoin (Macrodantin)
Phenytoin (Dilantin)
Vincristine (Oncovin)
Zalcitabine (Hivid)
Zidovudine (Retrovir)
Remember, too, that combination therapy with STAVIR (Stavudine, Zerit, d4T), Videx, and hydroxyurea
increases the possibility of serious liver problems. Combining STAVIR (Stavudine, Zerit, d4T)
and Videx also increases the risk of pancreatitis.
Special information if you are pregnant or breastfeeding
The possibility that STAVIR (Stavudine, Zerit, d4T) may harm a developing baby has not been
ruled out. The drug should be used during pregnancy only if its benefits
seem to outweigh the possible risk. The combination of STAVIR (Stavudine, Zerit, d4T) and Videx
should be used with particular caution during pregnancy due to the
danger of liver damage.
Do not breastfeed; HIV can be passed to a newborn infant through breast
milk.
Recommended dosage for STAVIR (Stavudine, Zerit, d4T)
ADULTS
Overdosage
Numbness, pain, and tingling of the hands and feet can be signs of
an overdose. If you suspect an overdose, seek medical attention immediately.
