Brand
name : TRXAMIC 500 (Tranexamic Acid, Cyklokapron)
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Adult
Dosing
Dosage forms: 500; IV
dental bleeding, hemophilia
25 mg/kg PO tid-qid x2-8 days
Start: 10 mg/kg IV x1 immed. preop; Alt: 25 mg/kg PO or 10 mg/kg IV tid-qid
x2-8 days starting 24h before tooth extraction
*bleeding prophylaxis, post-cardiac bypass
1 mg/kg/h IV
Start: 10 mg/kg IV x1; Alt: 10-12.5 mg/kg IV x1 at induction, then 1-10 mg/kg
x1 to prime pump, then 1-6.5 mg/kg/h IV; Info: protocols vary adjust dose
amount, frequency
Cr 1.36-2.83: 10 mg/kg IV bid or 15 mg/kg PO bid; Cr 2.83-5.66: 10 mg/kg
IV qd or 15 mg/kg PO qd; Cr >5.66: 10 mg/kg IV q48h or 5 mg/kg IV qd or
15 mg/kg PO q48h or 7.5 mg/kg PO qd; Info: recs apply to dental bleeding
use
only; adjustments not defined for other uses or IV infusion, conisder decr. Dose :
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Peds Dosing
Dosage forms: 500; IV
dental bleeding, hemophilia<18 yo :
Dose: 25 mg/kg PO tid-qid x2-8 days; Start: 10 mg/kg IV x1 immed. preop; Alt:
25 mg/kg PO or 10 mg/kg IV tid-qid x2-8 days starting 24h before tooth extraction
*bleeding prophylaxis, post-cardiac bypass 2 mo-15 yo
Dose: 1 mg/kg/h IV; Start: 10 mg/kg IV x1; Alt: 10 mg/kg IV x1 at induction,
then 1-10 mg/kg x1 on pump, then 10 mg/kg IV x1 at protamine; Info: protocols
vary adjust dose amount, frequency
renal impairment: dose adjustment may be required although specific pediatric
dosing adjustments not defined; see adult renal dosing for guidance
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Contraindications/Cautions
* hypersens. to drug/class/compon. * color vision defect, acquired * subarachnoid administration * Factor IX
use * anti-inhib. coag complex use * caution if renal dysfxn * caution if
upper urinary tract bleeding * caution if thromboembolic dz hx * caution
if DIC
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Drug Interactions
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Avoid/Use Alternative :* anti-inhibitor coagulant complex
Caution Advised
* thrombolytics TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Adverse Reactions
Serious Reactions
* retinal degeneration * retinal vein thrombosis *
retinal artery thrombosis * ureteral obstruction * thrombosis,
venous * thrombosis, arterial * visual changes
Common Reactions
* nausea/vomiting * diarrhea * giddiness * hypotension *
thromboembolism TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Safety Monitoring
Monitoring Parameters: Cr at baseline, then in elderly pts cont. periodically;
ophthal. exams at baseline and periodically thereafter if continual
tx longer than several days
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Pharmacology
Metabolism: liver minimally; CYP450: unknown
Excretion: urine (>95% unchanged); Half-life: 2h
Class: Bleeding Disorders
Mechanism Of Action inhibits plasminogen activators, interfering
w/ fibrinolysis
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Manufacturer/Pricing
Manufacturer: Pfizer U.S. Pharmaceuticals
DEA/FDA: Rx
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Patient Education
Patient education material for this drug is not currently available.
Every effort has been made to ensure that the information provided
by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled
for use by healthcare practitioners and consumers in the United States
and therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients
or recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as
a supplement to, and not a substitute for, the expertise, skill, knowledge
and judgment of healthcare practitioners. The absence of a warning
for a given drug or drug combination in no way should be construed
to indicate that the drug or drug combination is safe, effective or
appropriate for any given patient. Multum does not assume any responsibility
for any aspect of healthcare administered with the aid of information
Multum provides.
The information contained herein is not intended to cover all possible
uses, directions, precautions, warnings, drug interactions, allergic
reactions, or adverse effects. If you have questions about the drugs
you are taking, check with your doctor, nurse or pharmacist.
TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Pill Pictures
