Brand name:
Asacol - Mesalazine,
Messalamine, 5-ASA, Pentasa, Rowasa
Pronounced: ROH-ace-ah
Generic name: Mesalamine
Other brand names: Asacol, Canasa, Pentasa
Why is Asacol prescribed?
Asacol Suspension Enema, Pentasa, and Asacol are used to treat mild
to moderate ulcerative colitis (inflammation of the large intestine
and rectum). Asacol Suspension Enema is also prescribed for inflammation
of the lower colon, and inflammation of the rectum.
Asacol Suppositories and Canasa Suppositories are used to treat inflammation
of the rectum.
Most important fact about Asacol
Mesalamine, the active ingredient in these products, has been known
to cause side effects such as:
Bloody diarrhea
Cramping
Fever
Rash
Severe headache
Sudden, severe stomach pain
If you develop any of these symptoms, stop taking Asacol and consult
your doctor.
How should you use Asacol (Mesalazine, Messalamine,
5-ASA, Pentasa, Rowasa) without prescriptions?
To Use Asacol Suspension Enema
1. Asacol Suspension Enema comes in boxes of 7 bottles each. After
the foil on the box has been unwrapped, all Asacol Suspension Enemas
should be used promptly, following your doctor's instructions. The
Suspension Enema is normally off-white to tan in color, but may darken
over time once its foil cover is unwrapped. You may still use the
enema if it is slightly discolored, but do not use Asacol Suspension
Enema if it is dark brown. If you have any questions about using
Asacol Suspension Enema, contact your doctor.
2. Use Asacol Suspension Enema at bedtime.
3. Shake the bottle thoroughly.
4. Uncover the applicator tip.
5. You may find it easier to use Asacol Suspension Enema if you lie
down on your left side, extending your left leg and bending your right
leg forward for a comfortable balance. An alternative position is on
your knees with your hips in the air and your head and shoulders down
on the bed.
6. Pointing the applicator tip slightly towards the navel, gently insert
the tip into the rectum.
7. Tilt the bottle slightly towards the back, then squeeze it slowly
to discharge the contents.
8. Remain in position for at least 30 minutes to allow thorough distribution
of the medicine. Retain the enema all night (8 hours) for best results.
To Use Asacol or Canasa Suppositories
1. Asacol Suppositories should be used twice a day. Canasa Suppositories
can be used 2 or 3 times a day.
2. You should handle the suppositories as little as possible, because
they are designed to melt at body temperature.
3. Remove one suppository from the strip of suppositories.
4. While holding the suppository upright, carefully remove the wrapper.
5. Using gentle pressure, insert the suppository (with the pointed
end first) completely into the rectum. A small amount of lubricating
gel may be used on the tip of the suppository to assist insertion.
6. The suppository should be retained for 1 to 3 hours or longer for
best results.
To take Asacol (Mesalazine, Messalamine, 5-ASA, Pentasa, Rowasa) without
prescriptions
Swallow the capsule or tablet whole. Do not break, crush, or chew
it before swallowing.
You may notice what looks like small beads in your stool. These are
just empty shells that are left after Asacol has been absorbed into
your body. However, if this continues, check with your doctor.
If you miss a dose Asacol (Mesalazine, Messalamine, 5-ASA, Pentasa,
Rowasa)
Take it as soon as you remember. If it is almost time for your next
dose, skip the one you missed and go back to your regular schedule.
Never take 2 doses at the same time.
Storage instructions...
Store these products at room temperature. Keep suppositories away
from direct heat, light, and humidity. Do not refrigerate.
Asacol (Mesalazine, Messalamine, 5-ASA, Pentasa, Rowasa) side effects
Side effects cannot be anticipated. If any side effects develop or
change in intensity, tell your doctor immediately. Only your doctor
can determine whether it is safe to continue using this medication.
* Side effects generally include:
Diarrhea, dizziness, flu-like symptoms, gas, headache, nausea, stomach pain
* Other typical side effects may include:
Abdominal pain, acne, back pain, belching, bloating, chest pain, chills, constipation,
fever, hair loss, hemorrhoids, indigestion, insomnia, itching, joint pain,
leg pain, liver disorders, menstrual problems, muscle pain, nasal inflammation,
rash, rectal pain or bleeding, sore throat, stomach and intestinal bleeding,
sweating, swelling of the arms and legs, tiredness, urinary burning, vomiting,
weakness
Why should Asacol not be prescribed?
These products should not be used by anyone who is allergic or sensitive
to mesalamine or their other ingredients.
Pentasa, Canasa, and Asacol should not be used if you are allergic
or sensitive to salicylates (aspirin), foods, preservatives, or dyes.
Special warnings about Asacol
Your doctor should check your kidney function while you are taking
mesalamine, especially if you have a history of kidney disease or you
are using other anti-inflammatory drugs such as Dipentum.
Because older adults tend to have weaker kidneys, mesalamine is more
likely to trigger side effects within this age group. The drug also
seems more prone to cause blood disorders in older adults. If you are
65 or older, be sure to tell the doctor about any change in your health.
You should use mesalamine cautiously if you are allergic to sulfasalazine
(Azulfidine). If you develop a rash or fever, you should stop using
Asacol and notify your doctor.
Some people using mesalamine have developed flare-ups of their colitis.
Inflammation of the pancreas has also been reported.
Rare cases of pericarditis, in which the membrane surrounding the
heart becomes inflamed, have been reported with products containing
mesalamine. Symptoms may include chest, neck, and shoulder pain, and
shortness of breath.
Asacol Suspension Enema contains a sulfite that may cause allergic
reactions in some people. These reactions may include shock and severe,
possibly fatal asthma attacks. Most people aren't sensitive to sulfites.
However, some people with asthma might be sensitive and should take
any medication containing sulfites cautiously.
Asacol Suspension Enema may stain clothes and fabrics. Canasa Suppositories
can also stain surfaces, including marble, granite, plastic, and painted
surfaces.
Possible food and drug interactions when taking Asacol
If these products are taken with certain other drugs, the effects
of either could be increased, decreased, or altered. It is especially
important to check with your doctor before combining Asacol Suspension
Enema, Asacol Suppositories, and Canasa Suppositories with sulfasalazine
(Azulfidine).
Special information if you are pregnant or breastfeeding
Pregnant women should use mesalamine only if clearly needed. Mesalamine
has been found in breast milk. If Asacol is essential to your health
your doctor may advise you to discontinue breastfeeding until your
treatment is finished.
Recommended dosage for Asacol
ADULTS
Overdosage
* There have been no proven reports of serious effects resulting
from overdoses of Asacol or Canasa. An overdose of Pentasa or Asacol
could cause any of the following symptoms:
Confusion, diarrhea, drowsiness, headache, hyperventilation, ringing in the
ears, sweating, vomiting
Any medication taken in excess can have serious consequences. If you
suspect an overdose, seek medical attention immediately.
